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■神戸朝日病院
--神戸市第二次救急病院--
〒653-0801
神戸市長田区房王寺町3-5-25
連絡先
電話：
078-612-5151（代）
ＦＡＸ：078-612-5152
email：info@kobe-asahi-hp.com |
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TTV-positivity and transfusion
history in non-B and non-C HCC compared
with HBV- and HCV-positive cases |
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Background A novel agent, TT virus (TTV), transmitted
through transfusion and cloned by Japanese investigators, is
a single‐stranded DNA virus withａ full sequence of 3739 bp stored
in the Gene Bank (AB008394). Although a novel DNA virus with
a possible capability of inducing non- A to non-G hepatitis,
the precise role of TTV in hepatocarcinogenesis is unknown.
The main route of TTV infection is thought to be hereditary
or through transfusion; however, the role of transfusion in
TTV -positive HCC cases has not been elucidated.
Aim In order to study the role of TTV in hepatocarcinogenesis
of non-B, non-C (NBNC) HCC and the transfection route in TTV-
positive HCC, we investigated the frequency of TTV, and its
transfusion history in NBNC HCC as compared with HBV- and HCV-
positive cases of HCC.
Patients and methods One hundred and ninety‐nine cases of HCC
(HBV-positive 21,HCV-positive 152, HBV- and HCV-positive 6,andNBNC
20）treated from 1988 to 1998 at Kobe Asahi Hospital were examined
by diagnostic imaging or histologic analysis of biopsy specimens,
or both. PCR for the determination and sequencing of TTV DNA
was done as previously.(Okamoto H, et al. Hepatol Res 1998;
10:1-16.) Transfusion history of the one hundred and ninety-nine patients was confirmed
by professional medical personnel at our hospital.
Results Serum was positive for TTV in 77.８％(7/9）of HBV-positive,
36.4％ (12/33）of HCV-positive, 63.6％（7/11）of non-B non-C cases
of HCC. The rate through transfusion was 52.4％（11/21）in HBV-positive,
40.1％（61/152）in HCV- positive，33.3％ (2/6) in HBV+HCV-positive，and
40％ (8/20) in non-B，non-C HCCs, while it was 48.3% (14/29)
in TTV-positive and 39.3%(11/28) in TTV-negative cases.
Conclusion The association between TTV and HCC was limited,
and the main route of infection of TTV was not through transfusion.
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